Severe T Cell Defects
Severe T cell defects - Patients with SCID may develop life-threatening infections when exposed to wild-type varicella or vaccine-strain varicella. Patients with other severe T cell deficiencies are also at risk for similar infections (ex. MHC class II deficiency, Wiskott-Aldrich). Cutaneous Varicella zoster infections have been reported in patients with DOCK8 deficiency.
Severe NK Cell Defects
Severe NK cell defects -Several patients with absence of NK cells and severe disseminated varicella have been reported. Patients with immunodeficiencies resulting in impaired NK cell development or function can have severe infections with herpes viruses such as varicella (ex. NEMO, IKBA, Wiskott-Aldrich, CD16 deficiency, Familial HLH).