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TLR3 Mutation


TLR3 mutation - A mutation in TLR3 has been reported in 1 of 3 patients with influenza-associated encephalopathy. TLR3 deficiency has also been reported in two patients with HSV encephalitis. TLR3 is important for innate viral defense through the induction of IFN alpha/beta.

Severe T Cell Defects


Severe T cell defects - Patients with severe T cell defects such as SCID may develop life-threatening infections when exposed to influenza virus. Patients with other severe T cell deficiencies are also at risk for severe influenza infections (ex. MHC class II deficiency, Wiskott-Aldrich, ZAP70 deficiency, complete DiGeorge, etc).

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