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Serious T Cell Defects


Serious T cell defects - Patients are at risk for developing invasive CMV infections. Examples include diseases such as SCID, complete DiGeorge Syndrome, MHC Class II Deficiency, cartilage hair hypoplasia, and ZAP70 deficiency.




NEMO Deficiency


NEMO deficiency - Patients with CMV sepsis and colitis have been reported.




X-Linked Hyper IgM


X-linked Hyper IgM - Patients with CMV pneumonia, sclerosing cholangitis, or CNS infections have been reported.



X-Linked Lymphoproliferative Syndrome (XLP)


X-linked lymphoproliferative syndrome (XLP) - Patients often develop fatal fulminant EBV infections. Patients who survive acute EBV infections will often go on to develop hypogammaglobulinemia or lymphoma.




Familial Hemophagocytic Lymphohistiocytosis


Familial hemophagocytic lymphohistiocytosis (FHL) - Patients can develop uncontrolled proliferation of activated lymphocytes and histiocytes following EBV infection. Patients develop fever, hepatosplenomegaly, pancytopenia, and hemophagocytosis.




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