CMV & EBV
Serious T Cell Defects
Serious T cell defects - Patients are at risk for developing invasive CMV infections. Examples include diseases such as SCID, complete DiGeorge Syndrome, MHC Class II Deficiency, cartilage hair hypoplasia, and ZAP70 deficiency.
NEMO deficiency - Patients with CMV sepsis and colitis have been reported.
X-linked Hyper IgM - Patients with CMV pneumonia, sclerosing cholangitis, or CNS infections have been reported.
X-linked lymphoproliferative syndrome (XLP) - Patients often develop fatal fulminant EBV infections. Patients who survive acute EBV infections will often go on to develop hypogammaglobulinemia or lymphoma.
Familial hemophagocytic lymphohistiocytosis (FHL) - Patients can develop uncontrolled proliferation of activated lymphocytes and histiocytes following EBV infection. Patients develop fever, hepatosplenomegaly, pancytopenia, and hemophagocytosis.