HPV

 

 

WHIM Syndrome

 

 

WHIM syndrome - Patients have a unique susceptibility to HPV-induced warts in addition to bacterial sinopulmonary infections and cutaneous abscesses. Immunity to other viral infections is intact. Some patients can have few or no warts while others have diffuse verrucous lesions. The exact mechanism for the HPV susceptibility is not known.

 

DOCK8 Deficiency

 

DOCK8 deficiency - Patients develop cutaneous HPV-induced cutaneous warts. Skin infections with Molluscum contagiosum, HSV, and Varicella zoster also occur.

 

Epidermodysplasia Verruciformis

 

Epidermodysplasia Verruciformis (EV) - Patients have an increased susceptibility to cutaneous HPV infections. The lesions present as flat warts or hypo/hyperpigmented macules. Approximately one-third of patients will develop non-melanoma skin cancers.

 

GATA2 Deficiency

 

GATA2 deficiency - Patients suffer from disseminated HPV and molluscum contagiosum infections. Patients also develop infections from atypical mycobateria and fungi (aspergillus, histoplasmosis).