Trisomy 21 Syndrome

 

 

Patients are easily recognized by the presence of upward slanting palpebral fissues, low nasal bridge with upturned nares, flat facies, macroglossia with tongue protrusion, and folded or dysplastic ears.  Immune abnormalities include decreased T cell number and function, impaired specific antibdody responses, decreased memory B cell numbers, and decreased phagocyte chemotaxis and oxidative burst function. 

Trisomy 21 Syndrome