ICF Syndrome

 

Patients are characterized by immunodeficiency (humoral and cell-mediated), centromeric instability, and facial anomalies.  The facial features are characterized by hypertelorism, flat nasal bridge, epicanthal folds, and low set ears.   Immune abnormalities may include decreased immunoglobulin levels as well as decreased T cell numbers and function. 

 

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ICF Syndrome