Staphylococcus Aureus (Invasive)
Chronic Granulomatous Disease - Staph aureus is a catalase positive gram positive bacteria that is one of the key pathogens causing disease in CGD. Pneumonia, skin and visceral organ abscesses, lymphadenitis, osteomyelitis, and bacteremia have all been reported.
STAT3 Deficiency -Staph aureus is the most common organism causing infections in this disease(skin abscesses and pneumonias). The mechanism of this susceptibility is due to impaired Th17 response which is required for neutrophil chemotaxis and prodution of animicrobial peptides.
IRAK4 Deficiency & MyD88 Deficiency
IRAK4 deficiency and MyD88 deficiency - Patients may develop invasive Staph aureus infections (cellulitis, sepsis, meningitis, osteomyelitis). These patients fail to manifest signs of inflammation (fevers, elevated CRP or ESR) despite having deep-seated infections. Invasive pneumococcal infections are also commonly seen in patients.