Chronic Granulomatous Disease - Salmonella is a catalase positive gram negative rod that has been reported to cause bacteremia in CGD patients. Infections often occur with Salmonella species with low pathogenicity.
Interferon gamma pathway defects - Invasive Salmonella infections can be a key feature of patients (IFN-gamma receptor deficiency and IL-12 receptor deficiency). Intact IL-12 and IFN-gamma signaling is required to activate phagocytes to destroy intracellular pathogens such as Salmonella and Mycobacteria.
Tyk 2 deficiency - Tyk2 is a molecule involved in the IL-12 signaling pathway. As a result, Salmonella infections can be seen in Tyk 2 deficiency, a form of autosomal recessive Hyper IgE syndrome.
STAT1 deficiency - Disseminated Salmonella infections have been described in patients with partial STAT 1 deficiency. STAT 1 is a key molecule involved in the IFN-gamma signaling pathway. Enteric infections with Salmonella have been reported in antibody deficiency syndromes (XLA and CVID). However, invasive infections are not typically seen in these immunodeficiencies.