Helicobacter - Flexispira -Campylobacter
XLA - Patients can present with subacute or chronic episodes of cellulitis or ulcers of the lower extremities with Helicobacter (non-pylori) species, Flexispira, or Campylobacter. Septic arthritis, osteomyelitis and bacteremia can also occur with these organisms. The treatment of these organisms can be very challenging. An extended course of combination oral and intravenous antibiotics for up to 12 months (ex. Meropenem, levofloxacin, azithromycin) may be required. Shorter antibiotic courses have been associated treatment failure and relapse.Campylobacter may also cause chronic enteritis in patients with XLA.
CVID - Patients can develop enteric infections with Campylobacter jejuni. Helicobacter pylori infection can cause chronic gastritis involving the antrum and corpus.