STAT3 Deficiency

 

 

 

Patients develop severe dermatitis and recurrent cutaneous bacterial skin infections with Staphylococcus. Patients also suffer from recurrent sinopulmonary infections. Patients develop pneumatoceles following pneumonias. In addition, they have musculoskeletal abnormalities including retained primary teeth, pathologic fractures, hyperextensible joints, coarse facial features, and scoliosis.

STAT3 Deficiency