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Phagocytes (neutrophils and macrophages) are innate immune cells that provide a first-line of defense against bacterial pathogens encountered by the body (the skin and lungs are main areas of contact with the external environment). Not surprisingly, infections commonly occur in the lungs and skin of patients with phagocyte defects. Recurrent bacterial skin abscesses should trigger concern for defects of neutrophil function, chemotaxis, or number.
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