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CVID - Patients are at risk for developing a number of GI tract pathologies including lymphoid nodular hyperplasia and inflammatory bowel disease. An enteropathy with villous blunting (resembling celiac disease) may be present but does not respond to dietary gluten removal. The risk of developing GI tract malignancies (lymphoma, adenocarcinoma) is increased 50 fold.y.
Leukocyte adhesion deficiency - Patients with colitis at initial presentation have been reported. Colitis in LAD differs histologically from Crohn's due to the absence of neutrophilic inflammation (due to impaired neutrophil migration). Instead, lesions are characterized by lymphocyte, plasma cell, and eosinophil infiltration and lack of granuloma formation.
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