CVID - Patients are at risk for developing a number of GI tract pathologies including lymphoid nodular hyperplasia and inflammatory bowel disease. An enteropathy with villous blunting (resembling celiac disease) may be present but does not respond to dietary gluten removal. The risk of developing GI tract malignancies (lymphoma, adenocarcinoma) is increased 50 fold.y.
X-linked Hyper IgM syndrome - Patients commonly develop infectious diarrhea from Cryptosporidium or Giardia. However, inflammatory bowel disease and nodular lymphoid hyperplasia have also been reported.