Coccidiomycosis

 

 

STAT1 (gain of function) Mutations

‚Äč

STAT1 (gain of function) mutations - Disseminated Histoplasmosis and Coccidiomycosis has been reported in patients with gain of function STAT1 mutations. Prolonged STAT1 phosphorylation, hypomethylation and dephosphorylation impair IFN-gamma restimulation which results in diminished Th1 immune responses.