Chronic granulomatous disease - Aspergillus species commonly cause infections in CGD and are a leading cause of mortality. Patients most commonly develop Aspergillus pneumonia or osteomyelitis. Aspergillus nidulans infections occur almost exclusively in CGD and cause a much higher rate of osteomyelitis and mortality than Aspergillus fumigatus. Aspergillus nidulans also exhibits a higher rate of resistance to amphotericin B. Exposure to Aspergillus through handling of mulch or hay can cause fulminant pneumonitis in CGD patients.
Hyper IgE syndrome - Aspergillus does not typically cause primary infection in patients with HIES. However, patients can develop superinfection of lung pneumatoceles with this organism.
GATA2 Deficiency - Patients suffer from fungal infections from Aspergillus and Histoplasmosis. Atypical mycobacterial and viral (HPV, molluscum contagiosum) infections also occur.