Candida

 

 

Severe T Cell Defects

 

Severe T cell defects - Patients can develop mucocutaneous candidiasis as well as other opportunistic infections such as Pneumocystis jiroveci pneumonia and CMV infections. Examples of severe T cell defects include SCID, Wiskott-Aldrich, complete DiGeorge, and MHC class II deficiency.

 

 

Chronic Granulomatous Disease

 

Chronic granulomatous disease - Although less common than Aspergillus, CGD patients can develop severe infections with Candida including meningitis, fungemia, pneumonia, lymphadenitis, and subcutaneous/visceral abscesses.

 

X-Linked Hyper IgM

 

X-linked Hyper IgM - Patients have been reported to develop oral candidiasis, candida esophagitis, and Candida fungemia.

 

 

Hyper IgE Syndrome

 

Hyper IgE syndrome - Chronic candidiasis of mucosal sites and nails is a common finding described in autosomal dominant (STAT3 deficiency) HIES (83%). Candida endocarditis, endophthalmitis, visceral candidiasis, multiple pulmonary nodules, and candida fungemia have also been reported in patients.

 

 

DOCK8 Deficiency

 

DOCK8 deficiency - Patients have been reported to develop candidiasis at high frequency. Additional infections commonly reported in patients include bacterial cutaneous and pulmonary infections as well as cutaneous viral infections.

 

 

APECED

 

 

APECED - This disease is caused by mutations in the autoimmune regulator (AIRE) gene. Patients have chronic mucocutaneous candidiasis (invasive disease is uncommon) as well as autoimmune endocrinopathies (adrenal insufficiency, hypoparathyroidism).

 

 

Chronic Mucocutaneous Candidiasis

 

Chronic mucocutaneous candidiasis (CMC) - Patients develop Candida infections of the skin, mucous membranes, and nails (invasive disease is uncommon). Specific defects in IL-17 immunity have been reported including CARD9 deficiency, gain of function STAT1 mutations, and IL17F/IL17RA mutations.