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X-Linked Hyper IgM


X-linked Hyper IgM (CD40L deficiency) - Patients are at risk for developing gastrointestinal infections with Cryptosporidium (most commonly causing a watery diarrhea). Sclerosing cholangitis is a serious complication of this infection that can result in terminal liver damage and premature mortality



Autosomal Recessive Hyper IgM Syndrome


Autosomal recessive Hyper IgM syndrome - Similar to patients with CD40L deficiency, Cryptosporidium infections and sclerosing cholangitis has been reported in patients with this disease.



MHC Class II Deficiency


MHC Class II deficiency - Progressive hepatic failure from ascending cholangitis due to Cryptosporidium infection occurs in over 50% of patients.



DOCK8 Deficiency


DOCK8 deficiency- Ascending cholangitis due to Cryptosporidium has been described in this disease and likely reflects underlying T cell immunodeficiency .

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