Complement Deficiencies

 

 

 

Recurrent meningitis with Neisseria is a feature of terminal complement defects (C5-C9) or alternative complement defects (Factor D and Properidin deficiency). Meningococcal infections with unusual serotypes (W-135, X, Y, and Z) are seen rather than typical serotypes (A, B, and C).

Terminal Complement Defects

Alternative Complement Defects